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Chlorpheniramine; Hydrocodone; Phenylephrine: Moderate The therapeutic effect of phenylephrine may be decreased in patients receiving phosphodiesterase inhibitors. Chlorpheniramine; Phenylephrine: Moderate The therapeutic effect of phenylephrine may be decreased in patients receiving phosphodiesterase inhibitors.

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Although specific interactions have not been studied, other CYP3A4 inhibitors, such as erythromycin, itraconazole, and grapefruit juice, would likely increase tadalafil exposure. Although specific interactions have Erectile dysfunction been studied, other HIV protease inhibitors would likely increase tadalafil exposure [see Dosage treatment for Erection Problem Administration 2. Although specific interactions have not been studied, other CYP3A4 inducers, such as carbamazepine, phenytoin, and phenobarbital, would likely decrease tadalafil exposure.

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In a similar study using tadalafil 20 mg, there were no clinically significant differences between tadalafil and placebo in subjects taking amlodipine. A ngiotensin II receptor blockers with and without other antihypertensives � A study was conducted to assess the normal erection of angiotensin II receptor blockers problems with erection tadalafil 20 mg. Subjects in the study were taking any marketed angiotensin II receptor blocker, either alone, as a component of a combination product, or as part of a multiple antihypertensive regimen.

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In cases of overdose, standard supportive measures should be adopted as needed. Hemodialysis contributes negligibly to tadalafil elimination. Tadalafil, an oral treatment for pulmonary arterial hypertension, is a selective inhibitor of cyclic guanosine monophosphate cGMP �specific phosphodiesterase type 5 PDE5.

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It is not possible to determine whether these events are related directly to the use of PDE5 inhibitors or to other factors. Physicians should discuss with patients the potential for tadalafil to augment the blood pressure-lowering effect of alpha-blockers and antihypertensive medications.

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